Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats

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成果类型：

期刊论文

作者：

Lan, Bin;Ge, Jin-wen;Cheng, Shao-wu;Zheng, Xi-long;Liao, Jun;...

通讯作者：

Wang, GZ

作者机构：

[Zheng, Xi-long; Wang, Guo-zuo; Cheng, Shao-wu; He, Chao; Wang, GZ; Rao, Zheng-qing; Liao, Jun; Lan, Bin; Ge, Jin-wen] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China.

[Zheng, Xi-long] Univ Calgary, Libin Cardiovasc Inst Alberta, Cumming Sch Med, Dept Biochem & Mol Biol,Hlth Sci Ctr, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Wang, GZ ] H

Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

CD71 antigen;Chinese drug;deferiprone;glutathione;iron;malonaldehyde;naotaifang extract;natural resistance associated macrophage protein 2;neuroprotective agent;phospholipid hydroperoxide glutathione peroxidase;reactive oxygen metabolite;solute carrier family 7 member 11;solute carrier protein;unclassified drug;glutathione peroxidase 4, rat;herbaceous agent;naotaifang;phospholipid hydroperoxide glutathione peroxidase;acute disease;adult;animal experiment;animal model;animal tissue;Article;brain ischemia;Chinese medicine;controlled study;ferroptosis;gene expression level;immunohistochemistry;iron metabolism;male;neuroapoptosis;neuroprotection;Nissl substance;nonhuman;priority journal;rat;real time polymerase chain reaction;signal transduction;Western blotting;animal;brain ischemia;drug effect;nerve cell;Animals;Brain Ischemia;Drugs, Chinese Herbal;Ferroptosis;Neurons;Phospholipid Hydroperoxide Glutathione Peroxidase;Rats;Signal Transduction

期刊：

结合医学学报：英文版

ISSN：

2095-4964

年：

2020

卷：

期：

页码：

344-350

DOI：

10.1016/j.joim.2020.01.008

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 81774033 and No. 81773736 ) and the Hunan Provincial Department of Education-funded Scientific Research Project (No. 18C0379 and No. 19A378 ).

机构署名：

本校为第一且通讯机构

摘要：

Objective: Our previous research showed that Naotaifang (a compound traditional Chinese herbal medicine) extract (NTE) has clinically beneficial effects on neurological improvement of patients with acute cerebral ischemia. In this study, we investigated whether NTE protected acute brain injury in rats and whether its effects on ferroptosis could be linked to the dysfunction of glutathione peroxidase 4 (GPX4) and iron metabolism. Methods: We established an acute brain injury model of middle cerebral artery occlusion (MCAO) in rats, in which we c...

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Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats

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