A Novel Tropoloisoquinoline Alkaloid, Neotatarine, from Acorus calamus L.

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成果类型：

期刊论文

作者：

Li, Juan;Li, Zhao-Xing;Zhao, Jian-Ping;Wang, Wei;Zhao, Xiao-Fang;...

通讯作者：

Li, Shun-Xiang

作者机构：

[Li, Shun-Xiang; Xu, Bo; Ren, Jie; Wang, Wei; Li, Juan; Zhao, Xiao-Fang] Hunan Univ Chinese Med, Hunan Prov Engn Res Ctr Bioact Subst Discovery TC, Changsha 410208, Hunan, Peoples R China.

[Li, Zhao-Xing] Southwest Univ, Coll Pharmaceut Sci & Chinese Med, Chongqing 400715, Peoples R China.

[Zhao, Jian-Ping; Khan, Ikhlas A.] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA.

[Li, Lin; Zhang, Lan] Capital Med Univ, Minist Educ, Key Lab Neurodegenerat Dis, Beijing 100053, Peoples R China.

通讯机构：

[Li, Shun-Xiang] H

Hunan Univ Chinese Med, Hunan Prov Engn Res Ctr Bioact Subst Discovery TC, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Acorus calamus L.;Araceae;Tropoloisoquinoline alkaloid;7H-Azuleno[1,2,3-ij]isoquinolin-7-one;PC12 cells

期刊：

Chemistry & Biodiversity

ISSN：

1612-1872

年：

2017

卷：

期：

页码：

e1700201-

DOI：

10.1002/cbdv.201700201

基金类别：

Key Laboratory of Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing, P. R. China; Administration of Traditional Chinese Medicine of Hunan Province, P. R. China [201577]; Scientific Research Fund of the Hunan Provincial Education Department, Hunan Province, P. R. China [15C0114]

机构署名：

本校为第一且通讯机构

摘要：

A novel tropoloisoquinoline alkaloid, neotatarine (1), was isolated from the 95% ethanol extract of the rhizome parts of Acorus calamus L. The chemical structure was unambiguously elucidated by spectroscopic and single-crystal X-ray diffraction analysis. Neotatarine (1) exhibited significantly inhibitory activity against Aβ 25 – 35 induced PC12 cell death with 2, 4 and 8 μm comparing with the assay control (P < ...

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A Novel Tropoloisoquinoline Alkaloid, Neotatarine, from Acorus calamus L.

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