期刊论文

中文

数字中医药(英文)

2096-479X

2021

4

02

130-143

10.1016/j.dcmed.2021.06.006

本校为第一机构

目的基于网络药理学探讨黄芪-金樱子治疗良性前列腺增生症(BPH)的作用机制及作用靶点的实验验证。方法通过检索TCMSP、BATMAN-TCM数据库以及文献查阅,筛选出黄芪和金樱子的有效活性成分及相关靶基因。检索GeneCards、DisGeNET数据库,使用Excel软件合并去重,得到良性前列腺增生症相关靶基因。使用Perl语言获取“药物-疾病”交集靶基因数据库。使用Cytoscape 3.7.2软件构建“中药-成分-靶基因网络图”。将“药物-疾病”交集靶基因输入到STRING数据库,依据Degree算法筛选出核心靶基因。在此基础上,采用GO富集分析和KEGG通路富集探析黄芪-金樱子治疗BPH可能的作用机制和通路。采用黄芪-金樱子提取液...

This study aimed to analyze the mechanism of action of Huangqi (Astragalus Radix, HQ) - Jinyingzi (Rosae Laevigatae Fructus, JYZ) in the treatment of benign prostatic hyperplasia (BPH) based on network pharmacology and to verify the prediction through animal experimentation. Based on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (BATMAN-TCM) databases, and literature, the active components and related target genes...