CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway

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成果类型：

期刊论文

作者：

Wu, Di;Jiang, Wang;Liu, Caixia;Liu, Lexin;Li, Furong;...

通讯作者：

Xiang, Yang

作者机构：

[Pan, Lang; Liu, Chi; Li, Furong; Qu, Xiangping; Liu, Huijun; Qin, Xiaoqun; Liu, Lexin; Ma, Xiaodi; Wu, Di; Xiang, Yang] Cent South Univ, Sch Basic Med Sci, Dept Physiol, Changsha, Peoples R China.

[Jiang, Wang] Capital Med Univ, Sch Basic Med Sci, Dept Med Microbiol & Parasitol, Beijing, Peoples R China.

[Liu, Caixia] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha, Peoples R China.

[Xiang, Yang] Cent South Univ, Xiangya Sch Med, Dept Physiol, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Xiang, Yang] C

Cent South Univ, Xiangya Sch Med, Dept Physiol, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

asthma;CTNNAL1;HDM;MUC5AC;ROCK2;YAP

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2022

卷：

期：

页码：

1656-1671

DOI：

10.1111/jcmm.17206

基金类别：

NSFCNational Natural Science Foundation of China (NSFC) [81970033, 31900424, 82070034]; Hunan Natural Science FoundationNatural Science Foundation of Hunan Province [2020JJ4776, 2020JJ4688, 2019JJ50760, 2021JJ30898]; Open Foundation of Hunan College Innovation Program [20K142]; Central South University

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

Our previous study indicated that adhesion molecule catenin alpha-like 1(CTNNAL1) is downregulated in airway epithelial cells of asthma patients and asthma animal model but little is known about how the CTNNAL1 affects asthma pathogenesis. To reveal the direct relationship between asthma and CTNNAL1, CTNNAL1-deficient mouse model in bronchopulmonary tissue was constructed by introducing CTNNAL1-siRNA sequence using adeno-associated virus (AAV) as vector. The mouse model of asthma was established by stimulation of house dust mite (HDM). After HD...

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CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway

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