期刊论文

Zheng, XL

英文

International Journal of Molecular Sciences

1661-6596

2023

24

20

15160-

10.3390/ijms242015160

This review was supported by the Canadian Institutes of Health Research (CIHR, PJT178010 to X.-L. Zheng, PJT-165941 to X.-L. Zheng), the Natural Sciences and Engineering Research Council of Canada (RGPIN-2020-04592 to X.-L. Zheng), Key Discipline of Basic Medicine, Hunan University of Chinese Medicine (202302), the Science and Technology Innovation Program of Hunan Province (grant no. 2021RC4064), Key Laboratory of Vascular Biology and Translational Medicine, Hunan University of Chinese Medicine, and Basic Research Center of Integrated Chinese and Western Medicine for Prevention and Treatment of Vascular Diseases, Medical School, Hunan University of Chinese Medicine.

本校为第一机构

Endothelial cells (ECs) form the inner linings of blood vessels, and are directly exposed to endogenous hazard signals and metabolites in the circulatory system. The senescence and death of ECs are not only adverse outcomes, but also causal contributors to endothelial dysfunction, an early risk marker of atherosclerosis. The pathophysiological process of EC senescence involves both structural and functional changes and has been linked to various factors, including oxidative stress, dysregulated cell cycle, hyperuricemia, vascular inflammation, and aberrant metabolite sensing and signaling. Mul...