Targeting TRPV1 on cellular plasticity regulated by Ovol 2 and Zeb 1 in hepatocellular carcinoma

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成果类型：

期刊论文

作者：

Xie, Chengzhi;Liu, Guoxing;Li, Min;Fang, Yu;Qian, Ke;...

通讯作者：

Xu, Xundi;Wang, Jianxin

作者机构：

[Qian, Ke; Hu, Jixiong; Liu, Guoxing; Mori, Masaki; Fang, Yu; Zhong, Dewu; Huang, Zhao; Liu, Jiefeng; Zhang, Yueming; Wu, Xiaolong; Hu, Zecheng; Xie, Chengzhi; Huang, Shengfu; Li, Xiaocheng; Liu, Gao; Huang, Jiangsheng; Yamamoto, Hirofumi; Lei, Xiaohua; Liu, Qiang; Cao, Zhenyu; Xu, Xundi] Cent South Univ, Xiangya Hosp 2, Dept Surg, Hunan Prov Key Lab Hepatobiliary Dis Res,Div Hepa, Renmin Zhong Rd 139, Changsha 410011, Hunan, Peoples R China.

[Li, Min; Wang, Jianxin; Tang, Yu; Wu, Fangxiang] Cent South Univ, Dept Comp Sci & Technol, Sch Informat Sci & Engn, Lushan South Rd 293, Changsha 410083, Hunan, Peoples R China.

[Xie, Chengzhi] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Gen Surg, Changsha 410005, Hunan, Peoples R China.

[Wu, Fangxiang] Univ Saskatchewan, Coll Engn, Dept Mech Engn, Div Biomed Engn, 57 Campus Dr, Saskatoon, SK, Canada.

[Wang, Jun] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA.

通讯机构：

[Xu, Xundi; Wang, Jianxin] C

Cent South Univ, Xiangya Hosp 2, Dept Surg, Hunan Prov Key Lab Hepatobiliary Dis Res,Div Hepa, Renmin Zhong Rd 139, Changsha 410011, Hunan, Peoples R China.

Cent South Univ, Dept Comp Sci & Technol, Sch Informat Sci & Engn, Lushan South Rd 293, Changsha 410083, Hunan, Peoples R China.

语种：

英文

关键词：

HCC;TRPV1;Hepatocarcinogenesis;EMT;Zeb1;Ovol2

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2019

卷：

118

期：

118

页码：

109270

DOI：

10.1016/j.biopha.2019.109270

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81071716, 81171933]; National High-tech Research and Development Program of ChinaNational High Technology Research and Development Program of China [2006AA02Z336]

机构署名：

本校为其他机构

院系归属：

第二中医临床医学院

摘要：

The landscape of cellular plasticity and sources with relevant niche signals in hepatocellular carcinoma is still obscure. Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, is involved in a variety of malignancies and overexpressed in hepatocellular carcinoma (HCC). We have investigated the role of TRPV1 in HCC from different angles by various experimental techniques, such as in vivo and in vitro experiments, and by bioinformatics analysis of data from genetic models induced by diethylnitrosamine (DEN), mice samp...

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Targeting TRPV1 on cellular plasticity regulated by Ovol 2 and Zeb 1 in hepatocellular carcinoma

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