Efficacy and safety of naotaifang capsules for hypertensive cerebral small vessel disease: Study protocol for a multicenter, randomized, double-blind, placebo-controlled clinical trial

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成果类型：

期刊论文

作者：

Fang, Rui;Hu, Hua;Zhou, Yue;Wang, Shanshan;Mei, Zhigang;...

作者机构：

[Peng, Xiwen; Shang, Hongcai; She, Ruining; Ge, Jinwen; Meng, Pan; Cheng, Shaowu; Wang, Shanshan; Fang, Rui; Wang, Xiangyuan; Lin, Hongyuan; Mei, Zhigang; Zhou, Yue] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha, Hunan, Peoples R China.

[Ge, Jinwen; Fang, Rui] Hunan Acad Chinese Med, Inst Clin Pharmacol Chinese Mat Med, Changsha, Hunan, Peoples R China.

[Hu, Hua] Hunan Univ Chinese Med, Neurol Dept, Hosp 1, Changsha, Hunan, Peoples R China.

[Jiang, Qiling; Liu, Litao] Shaoyang Univ, Sch Food & Chem Engn, Shaoyang, Hunan, Peoples R China.

[Wu, Dahua; Xie, Yao; Xie, Le] Hunan Prov Hosp Integrated Chinese & Western Med, Hunan Acad Chinese Med Affiliated Hosp, Neurol Dept, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Hypertensive cerebral small vessel disease;randomized controlled trial;Chinese medicine;Naotaifang capsule;Treatment

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2023

卷：

页码：

4847

DOI：

10.3389/fphar.2022.967457

基金类别：

National Key Research and Development Program of the Ministry of Science and Technology [2018YFC1704904]; Key Research and Development Program of Hunan Province [2022SK2016]; Scientific Research Program of Educational Department of Hunan Province [20B436]; Hunan Provincial TCM Research Program [D2022071]; Scientific Research Program of Health Commission of Hunan Province [202103102090]; Key discipline projects of Hunan University of Chinese Medicine [2021ZXYJH01]; Scientific Research Fund Program of Hunan University of Chinese Medicine [2020XJJJ025]

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

中西医结合学院

摘要：

Background: Hypertensive cerebral small vessel disease (HT-CSVD) is a cerebrovascular clinical, imaging and pathological syndrome caused by hypertension (HT). The condition manifests with lesions in various vessels including intracranial small/arterioles, capillaries, and small/venules. Hypertensive cerebral small vessel disease has complex and diverse clinical manifestations. For instance, it can present as an acute stroke which progresses to cause cognitive decline, affective disorder, unstable gait, dysphagia, or abnormal urination. Moreover, hypertensive cerebral small vessel disease cause...

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Efficacy and safety of naotaifang capsules for hypertensive cerebral small vessel disease: Study protocol for a multicenter, randomized, double-blind, placebo-controlled clinical trial

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