Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation

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成果类型：

期刊论文

作者：

Zheng, Jun;Fan, Rong;Wu, Huiqiong;Yao, Honghui;Yan, Yujie;...

通讯作者：

Zhang, Yi;Tang, Tao;Wang, Yang

作者机构：

[Zhang, Yi; Wu, Huiqiong; Sun, Zhifang; Zheng, Jun] Cent South Univ, Coll Chem & Chem Engn, Key Lab Hunan Prov Water Environm & Agr Prod Safe, Changsha 410083, Hunan, Peoples R China.

[Fan, Rong; Zhang, Yi; Wang, Yang; Zhang, Y; Tang, Tao] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Key Lab Hunan Prov Liver Manifestat Tradit Chines, Changsha 410008, Hunan, Peoples R China.

[Wu, Huiqiong] Zhengzhou Univ, Minist Educ, Key Laboratry Mat Proc & Mold, Zhengzhou 450002, Henan, Peoples R China.

[Liu, Jiamiao; Yan, Yujie; Yao, Honghui] Cent South Univ, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.

[Yi, Lunzhao; Ran, Lu] Kunming Univ Sci & Technol, Yunnan Food Safety Res Inst, Kunming 650500, Yunnan, Peoples R China.

通讯机构：

[Zhang, Yi; Zhang, Y; Tang, T; Wang, Y] C

Cent South Univ, Coll Chem & Chem Engn, Key Lab Hunan Prov Water Environm & Agr Prod Safe, Changsha 410083, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Inst Integrat Med, Key Lab Hunan Prov Liver Manifestat Tradit Chines, Changsha 410008, Hunan, Peoples R China.

语种：

英文

期刊：

Nature Communications

ISSN：

2041-1723

年：

2019

卷：

期：

页码：

1604

DOI：

10.1038/s41467-019-09601-3

基金类别：

This work was supported by the National Natural Science Foundation of China (Nos. 81303074, 81673719, 21473257, and 21773311), the Outstanding Youth Foundation of Hunan Provincial Natural Science Foundation of China (No. 2019JJ30042), the Hunan Provincial Natural Science Foundation of China (No. 2019JJ50960), and the Special Program for Applied Research on Super Computation of NSFC-Guangdong Joint Fund. We are very grateful to Prof. Zhimou Yang from NanKai University for giving us guidance on experimental methods of using LC-MS to evaluate the stability of rhein gel in cells.

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack of knowledge about natural drug gels limits there current application. Here, we report on rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions. This hydrogel shows excellent stability, sustained release and reversible stimuli-responses. The hydrogel consists of a three-dimensional nanofiber network that prevents premature degrada...

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Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation

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