Objective To discuss application and effect of flipped classroom in the teaching of pathophysiology and form new teaching thoughts. Methods Shock chapter of the textbook was selected. Teaching plan based on the flipped classroom mode was designed and complemented. Control experiment and questionnaire survey were conducted to compare students’learning effects. Results The experiment group scored 82.48 while the control group scored 80.71 on average. In terms of excellent (scoring above 90) rate, the experiment group was 5.31%higher than the c...