期刊论文

Effect of Hewei Wenfei Mixture on Interleukin-4 and Interferonγ in Rats with Cough Variant Asthma

中文

亚太传统医药

1673-2197

2019

15

8

30-32

10.11954/ytctyy.201908008

湖南省财政厅2016教科文专项（湘财教指[2016]228号）；

本校为第一机构

目的:观测各组大鼠血清及肺泡灌洗液(BALF)中γ干扰素(IFN-γ)、白细胞介素4(IL-4)含量,以探讨和卫温肺合剂对调节咳嗽变异性哮喘(CVA)模型大鼠免疫功能紊乱的作用机制.方法:先将卵蛋白与氢氧化铝生理盐水混合液注射到实验大鼠腹部致敏,后用卵蛋白激发哮喘以建模,将造模成功后的大鼠分为正常组,模型组,和卫温肺合剂高剂量组、中剂量组、低剂量组,采用酶联免疫吸附剂测定法(ELISA)测定各组大鼠血清及肺泡灌洗液(BALF)中 γ干扰素(IFN-γ)和白细胞介素4(IL-4)的含量.结果:与正常组比较,模型组血清和支气管肺泡灌洗液(BALF)中IFN-γ含量明显降低(P

Objective:to observe the levels of interferon γ(IFN-γ)and interleukin-4(IL-4)in serum and alveolar lavage fluid(BALF)of rats in each group.To investigate the mechanism of Hewei Wenfei mixture on regulating immune dysfunction in(CVA)model of cough variant asthma.Methods:ovalbumin and aluminum hydroxide were injected into the abdomen of experimental rats to sensitize the rats,and then asthma was induced by ovalbumin.The rats were divided into normal group,model group and high dose group.Medium dose group and low dose group of Hewei Wenfei mixtu...