期刊论文

Effects of Qufeng Huoxue Pill on serum IL-35 and IL-10 expressions in rats with experimental autoimmune uveitis

中文

上海中医药大学学报

1008-861X

2018

32

3

62-66

10.16306/j.1008-861x.2018.03.013

81273808:国家自然科学基金 17A164:湖南省教育厅科学研究项目

本校为第一机构

目的:观察祛风活血丸对实验性自身免疫性葡萄膜炎（experimental autoimmune uveitis,EAU）模型大鼠血清中IL-35、IL-10表达的动态影响,探讨祛风活血丸对EAU的疗效和作用机制。方法:将80只Lewis大鼠随机分为空白组、模型组、阳性对照组及祛风活血丸低剂量组、高剂量组,每组16只。空白组不作处理,其余均予以右后足垫注射光感受器间维生素A结合蛋白（interphotoreceptor retinoid-binding protein,IRBP）建立EAU大鼠模型。空白组与模型组予以蒸馏水灌胃,祛风活血丸低剂量组和高剂量组分别予以不同剂量祛风活血丸药液灌胃,阳性对照组予以熊胆开明片药液灌胃,灌胃均14 d。自造模开始,每天于裂隙灯下...

Objective： To observe the effects of Qufeng Huoxue Pill on serum IL-35 and IL-10 expressions in rats with experimental autoimmune uveitis（ EAU）,and discuss the efficacy and mechanism of Qufeng Huoxue Pill on EAU. Methods： Eighty Lewis rats were randomly divided into the blank group,model group,positive control group,Qufeng Huoxue Pill groups with low-and high-dose,16 rats in each group. Except the blank group,the EAU model was established in the other groups by injection of interphotoreceptor retinoid-binding protein（ IRBP） in right rear ...