A new similarity method for assessment of pharmacokinetic interaction between flucloxacillin and midazolam

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成果类型：

期刊论文

作者：

Fan, Qimeng;Liu, Wenlong;Yang, Yantao;Zhou, Jin;Tang, Yu;...

通讯作者：

He, Fuyuan

作者机构：

[Fan, Qimeng; Tang, Yu; Zhou, Yiqun; Xiao, Meifeng; He, Fuyuan; Yang, Yantao; Zhou, Jin; Liu, Wenlong; Pan, Xue] Hunan Univ Chinese Med, Coll Pharm, Dept Pharmaceut, Changsha 410208, Hunan, Peoples R China.

[Fan, Qimeng; Tang, Yu; Zhou, Yiqun; Xiao, Meifeng; He, Fuyuan; Yang, Yantao; Zhou, Jin; Liu, Wenlong; Pan, Xue] Hunan Univ Chinese Med, Hunan Key Lab Druggabil & Preparat Modificat Trad, Affin Hosp 2, Changsha, Hunan, Peoples R China.

[Tang, Yu; Zhou, Yiqun; Xiao, Meifeng; He, Fuyuan; Zhou, Jin; Pan, Xue] Hunan Univ Chinese Med, Dept Supramol Mech & Math Phys Characterizat Chin, Affin Hosp 2, Changsha, Hunan, Peoples R China.

[Deng, Kaiwen] Hunan Univ Chinese Med, Dept Acupuncture, Affin Hosp 2, Changsha, Hunan, Peoples R China.

通讯机构：

[He, Fuyuan] H

Hunan Univ Chinese Med, Coll Pharm, Dept Pharmaceut, Changsha 410208, Hunan, Peoples R China.

语种：

英文

期刊：

Die Pharmazie

ISSN：

0031-7144

年：

2019

卷：

期：

页码：

397-405

DOI：

10.1691/ph.2019.9016

基金类别：

Scientific Research Fund of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573691, 81703824, 81874344, 81874507]; Hunan Provincial Education DepartmentHunan Provincial Education Department [17B200]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2017JJ3236]

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

The purpose of this study was to develop a new similarity method to assess the drug-drug interaction between midazolam and flucloxacillin. Total quantum statistical moment (TQSM) of pharmacokinetic profiles were expressed by parameters AUCT, MRTT, VRTT et al. Statistical moment similarity (SMS) expressions were deduced to evaluate the similarity of the converted pharmacokinetic profiles. A trial of the pharmacokinetic interaction between midazolam and flucloxacillin by the SMS method was conducted. For midazolam, total quantum SMS (SMST) was 0....

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A new similarity method for assessment of pharmacokinetic interaction between flucloxacillin and midazolam

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