Integrative analysis of the bladder cancer from a cell cycle NCAM1 perspective at both single cell and bulk resolution

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成果类型：

期刊论文

作者：

Zeng, Xiangju;Su, Hao;Liu, Ziqi;Wang, Yinhuai;Lu, Zhijie;...

通讯作者：

Cheng, SH

作者机构：

[Zeng, Xiangju] Cent South Univ, Dept Outpatient, Second Xiangya Hosp, Changsha, Hunan, Peoples R China.

[Cheng, Shunhua; Lu, Zhijie; Su, Hao; Wang, Yinhuai] Cent South Univ, Dept Urol, Second Xiangya Hosp, Changsha, Hunan, Peoples R China.

[Liu, Ziqi] First Hosp Hunan Univ Chinese Med, Dept Acupuncture & Moxibust, Changsha, Hunan, Peoples R China.

[Cheng, Shunhua; Cheng, SH] Cent South Univ, Dept Urol, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Cheng, SH ] C

Cent South Univ, Dept Urol, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

bladder cancer;cell cycle;cell proliferation;immune infiltration;NCAM1;prognosis

期刊：

ENVIRONMENTAL TOXICOLOGY

ISSN：

1520-4081

年：

2025

卷：

期：

页码：

445-458

DOI：

10.1002/tox.24260

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

针灸推拿与康复学院

摘要：

INTRODUCTION: Bladder cancer (BLCA) is a prevalent and deadly form of urinary cancer, and there is a need for effective therapies, particularly for muscle-invasive bladder cancer (MIBC). Cell cycle inhibitors show promise in restoring control of the cell cycle in BLCA cells, but their clinical prognosis evaluation is limited. METHODS: Transcriptome and scRNA-seq data were collected from the Cancer Genome Atlas Program (TCGA)-BLCA and GSE190888 cohort, respectively. R software and the Seurat package were used for data analysis, including cell quality control, dimensionality reduction, and ident...

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Integrative analysis of the bladder cancer from a cell cycle NCAM1 perspective at both single cell and bulk resolution

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