期刊论文

Cai, G.-X.

中文

中草药

0253-2670

2012

43

4

743-747

湖南省自然科学基金重点项目（09JJ3055） 湖南省科技厅资助项目（20107D2004）

本校为第一且通讯机构

目的观察马钱子粗粉和超微粉对佐剂性关节炎模型大鼠的干预作用,探讨其有效性、安全性的量效关系差异。方法采用佐剂性关节炎大鼠模型,马钱子超微粉与粗粉ig给药剂量分别为50.0、35.0、24.5、17.2、12.0 mg/kg,每天给药1次,连续给药21 d,测定试药对模型大鼠的足跖容积、超氧化物歧化酶（SOD）、丙二醛（MDA）、一氧化氮（NO）、肿瘤坏死因子-α（TNF-α）有效性评价指标的影响,以及对血液学指标、血液生化学指标、脏器指数等安全性评价指标的影响,并比较马钱子粗粉和超微粉最小起效剂量、有效剂量范围、最小中毒剂量。结果马钱子超微粉与粗粉均能明显降低模型大鼠的足跖容积,最低起效剂量分别为...

Objective: To observe the intervention effects of Strychni Semen Pulveratum (SSP) with different grain sizes and its ultramicro powder on the rats suffered from rheumatoid arthritis, and to discuss the difference of dose-effect relationship between efficacy and safety. Methods: The rats with adjuvant-induced arthritis were taken as model animals. Ultramicro powder and crude powder of Strychni Semen were ig administrated at the concentration of 50.0, 35.0, 24.5, 17.2, and 12.0 mg/kg, respectively for four weeks continuously. The influence of ult...