期刊论文

Optimization of spray drying technology of Liqi Huoxue Compound extract by Box-Behnken response surface method combined with G1-entropy weight method

Li, Y.

中文

中草药

0253-2670

2019

50

11

2560-2566

10.7501/j.issn.0253-2670.2019.11.009

国家自然科学基金资助项目(81673955) 湖南省教育厅科学研究重点项目(16A158) 湖南中医药大学一流学科建设项目(4901-0200002006).

本校为第一且通讯机构

目的优选理气活血复方浸膏的喷雾干燥工艺,并对浸膏粉进行质量评价。方法以药液相对密度、进风温度、空气体积流量为自变量,以阿魏酸、丹参酮II_A、丹酚酸B、葛根素含量与出粉率的综合评分为响应值,试验数据进行2项式拟合,建立综合评分指标与各自变量之间的数学关系,采用Box-Behnken设计-响应面法结合G1-熵权法优化理气活血复方浸膏的喷雾干燥工艺。结果最佳喷雾干燥工艺为药液相对密度1.08,进风温度140 ℃,空气体积流量40 m~3/h。在此条件下,浸膏喷雾干燥的平均阿魏酸质量分数为0.300 4 mg/g、丹参酮IIA质量分数为0.338 0 mg/g、丹酚酸B质量分数为18.526 0 mg/g、葛根素质量分数为7.508 8 mg/g...

Objective: To optimize the spray drying process of Liqi Huoxue Compound (LHC) extract and evaluate the quality of extract powder. Methods: The drug concentration, inlet air temperature and air flow were used as independent variables, and the comprehensive scores of ferulic acid, tanshinone IIA, salvianolic acid B, puerarin content and flour extraction rate were used as the response values, and the test data were binomial fitting. The mathematical relationship between the comprehensive scoring index and their respective variables was established...