期刊论文

Integrated analysis of “eighteen incompatible medicaments” of Chinese materia medica based on supramolecular imprinting interaction

He, F.-Y.

中文

中草药

0253-2670

2019

50

12

2777-2784

10.7501/j.issn.0253-2670.2019.12.004

国家自然科学基金项目(81573691) 国家自然科学基金项目(81703824) 湖南省科技厅重点实验室建设资助项目(2016TP1017) 湖南省自然科学基金项目(2016JJ4065) 湖南中医药大学研究生科研创新课题(2018CX18) 湖南省教育厅创新平台开放基金项目(18K071).

本校为第一且通讯机构

"十八反"是传统中药配伍禁忌的重要内容,涉及中药临床用药安全有效的关键基础问题。在前期提出的中医药超分子"印迹模板"自主作用规律的基础上,以中药"十八反"反药对为对象,对其当前研究基础进行整合分析。首先分析总结了中药"十八反"的历史沿革,再运用超分子"印迹模板"解析中药配伍:中药配伍是将2种或2种以上中药有效成分群（客体分子）之间以非共价键进行结合,形成新的超分子体系,再与人体（主体分子）发生印迹作用,按"印迹模板"产生药效与毒效,宏观上表现出中药的配伍规律。基于此,再从超分子化学角度分别对"十八反"各组药对进行整合分析,最后提出了"十八反"的化学动力学、网络动力学、谱毒效...

The “eighteen incompatible medicaments” is an important content of Chinese materia medica (CMM) compatibility contraindication, involving the key basic problem of safe and effective clinical use of CMM. Based on the rule of the automatic action of supramolecular “imprinting template” previously proposed, the current research basis of “eighteen incompatible medicaments” were integrated and analyzed. Firstly, the history of “eighteen incompatible medicaments” were summarized, then the theory of Chinese materia medica (CMM) compatibility w...