期刊论文

Optimization of water extraction technology of Yiqi Huoxue Prescription based on orthogonal test design and BP neural network

Li, Y.

中文

中草药

0253-2670

2019

50

18

4305-4312

10.7501/j.issn.0253-2670.2019.18.008

国家自然科学基金资助项目(81673955) 湖南省自然科学基金资助项目(2017JJ2206) 湖南中医药大学中药学一流学科建设项目(4901-0200002006).

本校为第一且通讯机构

目的 优化筛选益气活血方的水提工艺参数。方法 在单因素实验基础上,采用正交试验设计,以加水量、提取时间、浸泡时间为考察因素,丹酚酸B和羟基红花黄色素A的转移率及浸膏得率为评价指标,采用G1-熵权法赋权得到综合评分。通过正交试验设计进行分析得到最佳水提工艺,再通过BP神经网络建模进行网络模型优化和目标寻优。验证试验对比2种分析方法,寻找益气活血方的最佳水提工艺参数。结果 基于2种分析方法对比发现,正交试验分析得到最佳水提工艺的综合评分略高于BP神经网络建模结果,故最终确定该益气活血方最佳水提工艺参数为水提3次、浸泡0.5h、加水量20倍、提取时间3.5 h。结论 优选出的益气活血方...

Objective: To optimize the water extraction technology parameters of Yiqi Huoxue Prescription (YHP). Methods: On the basis of single factor experiment, orthogonal experiment design was used to evaluate the transfer rate and extraction yield of salvianolic acid B and hydroxysafflower yellow A by using adding water, extraction time and soaking time as factors. The comprehensive score was obtained by G1-entropy weight method. The optimal water extraction technology was obtained by orthogonal test design, and another method-BP neural network modeli...