期刊论文

Study on borneol combined with astragaloside IV and Panax notoginseng saponins promoting bioactive components into brain in cerebral ischemia/reperfusion model of rats

Huang, X.-P.

中文

中草药

0253-2670

2019

50

7

1649-1656

10.7501/j.issn.0253-2670.2019.07.023

国家自然科学基金资助项目(81573875) 湖南省自然科学基金项目(2018JJ3382) 湖南省中医药管理局重点项目(201509) 湖南省科技厅科技创新平台与人才计划——中医脑病临床研究中心(2017SK4005) “中医药防治心脑血管疾病基础研究”湖南省自然科学创新群体基金.

本校为第一且通讯机构

目的探讨冰片是否具有促进黄芪甲苷(AST IV)和三七总皂苷(PNS)配伍时主要有效成分透过大脑中动脉栓塞(MCAO)再灌注模型大鼠血脑屏障的作用。方法大鼠随机分为假手术组、模型组、冰片组、AST IV 组、PNS 组、AST IV+PNS组、冰片+AST IV+PNS 组,制备MCAO 再灌注大鼠模型,以液相色谱-质谱联用法(LC-MS/MS)测定大鼠患侧与健侧大脑皮层、小脑中AST IV和PNS 有效成分(人参皂苷Rg_1、Rb_1和三七皂苷R_1)的含量。结果 AST IV 无论是单用还是与 PNS、冰片配伍,其口服后主要分布在大脑皮层,尤其是患侧大脑皮层。冰片+AST IV+PNS 能使患侧与健侧大脑皮层中 AST IV 含量显著增加。PNS 单用,其有效成分人参皂...

Objective To investigate whether borneol can promote the bioactive components of the combination of astragaloside IV (AST IV) and Panax notoginseng saponins (PNS) into the blood-brain barrier of rats with middle cerebral artery occlusion (MCAO)/reperfusion. Methods Using the model of MCAO/reperfusion, rats were randomly divided into sham-operation group, model group, borneol group, AST IV group, PNS group, AST IV + PNS group and borneol + AST IV + PNS group, and the content of AST IV and the bioactive components of PNS (ginsenoside Rg1, ginseno...