期刊论文

Clinical efficacy and safety evaluation of diabetic nephropathy treatment with Yishen Huashi Granule combined with Tripterygium wilfordii polyglycosides Tablet

Li, X.

中文

中草药

0253-2670

2020

51

23

6045-6049

10.7501/j.issn.0253-2670.2020.23.017

江西省科技厅一般项目(S2016SFYBG0294) 江西省卫生健康委科技计划(20204305) 江西省中医药科研计划(2019A395)。

本校为第一且通讯机构

目的探讨益肾化湿颗粒联合雷公藤多苷片治疗糖尿病肾病(diabetic kidney disease,DKD)的疗效与安全性。方法筛选九江市中医院III~IV期DKD患者,随机分配入对照组(46例)及治疗组(46例)。在常规治疗基础上,对照组给予雷公藤多苷片,治疗组在对照组基础上施予益肾化湿颗粒,治疗持续3个月。检测并比较各组治疗前后尿微量蛋白、血清白蛋白、尿素氮、肌酐、血脂、尿IgG4、尿视黄醇结合蛋白改变。评估并记录中医证候积分。检测治疗后血常规、肝功能、细胞免疫,记录不良反应发生情况。结果治疗后,对照组和治疗组的总有效率分别是73.91%、86.96%,两组比较差异具有统计学意义(P

Objective: To study the clinical efficacy and safety of Yishen Huashi Granule (YHG) combined with Tripterygium wilfordii polyglycosides tablet (TWP) in the treatment of diabetic kidney disease (DKD). Methods: A total of 92 DKD patients in the stage of III-IV were selected from the department of nephropathy of the Jiujiang Hospital of Chinese Medicine. These patients were randomly divided into the observation group (46 cases) and the control group(46 cases). The observation group was treated with conventional therapy combined with TWP, and the c...