期刊论文

Mechanism of Astragali Radix-Angelicae Sinensis Radix compatibility active ingredients in improving intimal hyperplasia based on network pharmacology

Deng, C.-Q.

中文

中草药

0253-2670

2020

51

15

3987-3995

10.7501/j.issn.0253-2670.2020.15.018

国家自然科学基金资助项目(81874406)。

本校为第一机构

目的采用网络药理学方法探讨黄芪-当归配伍改善血管内膜增生的药效物质和可能的作用靶点。方法利用TCMSP数据库,获取黄芪-当归的有效成分,利用Pharmmaper数据库搜集活性成分所对应的靶标。通过Genecards、DigSeE和OMIM数据库,收集血管内膜增生相关的靶标,并与药物作用靶标相比较,筛选出共同部分,作为药物成分作用的预测靶标。利用STRING获取预测靶蛋白之间的相互关系,根据相互关系大小筛选出核心靶标。利用Cytoscape 3.6.1软件,绘制"药物-成分-疾病-靶标"网络图、核心靶标相互作用网络图。用R语言进行核心靶标的KEGG通路富集分析和GO生物过程分析。结果收集到黄芪-当归药对的20个活性成分,共得到...

Objective: To investigate the pharmacodynamics and possible targets of Astragali Radix (AR)-Angelicae Sinensis Radix (ASR) compatibility in improving intimal hyperplasia by using network pharmacology. Methods: The TCMSP database was used to obtain the active constituents of AR-ASR, and the Pharmmaper database was used to collect the targets corresponding to the active ingredients. Targets related to intimal hyperplasia were collected by Genecards, DigSeE, and OMIM databases, and compared with drug targets, common parts were screened as predicti...