期刊论文

Zhang, X.-L.;Liu, W.-L.

中文

中草药

0253-2670

2022

53

14

4298-4306

10.7501/j.issn.0253-2670.2022.14.009

81874344:国家自然科学基金 2021JJ30514:湖南省自然科学基金资助项目 2021073:湖南省中医药管理局项目 2021204:湖南省中医药管理局项目

本校为第一机构

目的 通过检测7种配伍及7个单味组成药的单个化学成分与总响应成分的溶出量及变化情况,探讨生血宝复方配伍理论背后的科学内涵.方法 根据生血宝复方中君臣佐使组方规律将各单味药重新进行配伍分组,建立16种成分(原儿茶酸、原儿茶醛、红景天苷、芍药苷、毛蕊异黄酮苷、二苯乙烯苷、木犀草苷、毛蕊异黄酮、特女贞苷、白藜芦醇、木犀草素、蟛蜞菊内酯、芒柄花素、旱莲苷A、大黄素、大黄素甲醚)同时含量测定的超高效液相色谱(UPLC)-二极管阵列检测器(PDA)方法学,并运用总量统计矩等方法进行定性定量分析.结果 7种配伍分组(君、臣、佐使、君加臣、君加佐使、臣加佐使、复方)16个成分的总溶出量前3位的...

Objective The scientific connotation behind the compatibility theory of the Shengxuebao compound was explored by detecting the dissolution and changes of a single chemical component and the total response component of seven compatibilities. Methods According to the prescription rules of monarch and minister assistants in the Shengxuebao compound, the single herbs were regrouped. The UPLC-PDA method was established for the simultaneous determination of 16 components (protocatechuic acid, protocatechuic aldehyde, salidroside, paeoniflorin, calyco...