Objective To examine the mechanism of Buyang Huanwu Decoction(补阳还五汤,BHD)on astrocyte trans-differentiation after cerebral ischemia based on caveolin-1(Cav1)/sonic hedgehog(Shh)signaling pathway.Methods Male C57BU6 mice were randomly divided into sham group,model group,BHD low-,medium-,high-dose(9.25,18.50,39.00 g/kg)groups and butylphthalide(54 mg/kg)group.Except the sham group,the other groups were treated with middle cerebral artery occlusion(MCAO)to replicate the cerebral ischemia model.Following 21 d of drug intervention,the efficacy o...
