The effects of fresh Gastrodia elata Blume on the cognitive deficits induced by chronic restraint stress

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成果类型：

期刊论文

作者：

Huang, Hong;Zhang, Yiwen;Yao, Caihong;He, Qinghu;Chen, Fang;...

作者机构：

[Zhang, Yiwen; Jiang, Ning; Yao, Caihong; Liu, Xinmin; Huang, Hong] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev IMPLAD, Res Ctr Pharmacol & Toxicol, Beijing, Peoples R China.

[He, Qinghu] Hunan Univ Med, Sino Pakistan Ctr Tradit Chinese Med, Huaihua, Peoples R China.

[Chen, Fang] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha, Peoples R China.

[Lu, Guanghua; Yu, Han] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu, Peoples R China.

[Liu, Xinmin] Ningbo Univ, Inst Drug Discovery Technol, Ningbo, Peoples R China.

语种：

英文

关键词：

Chronic restraint stress;Gastrodia elata Blume;learning and memory;animal behavior;Mitochondria

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2022

卷：

页码：

3439

DOI：

10.3389/fphar.2022.890330

基金类别：

International Cooperative Project of Traditional Chinese Medicine [GZYYG2020023]; National Key R&D Program of China [2018YFC1602105]; Key Laboratory of Agro-Products Processing, National Risk Assessment Laboratory of Agro-products Processing Quality and Safety, Ministry of Agriculture and Rural Affairs, China [S2021KFKT-02]

机构署名：

本校为其他机构

院系归属：

中医学院

摘要：

Chronic restraint stress (CRS) is a classic animal model of stress that can lead to various physiological and psychological dysfunctions, including systemic neuroinflammation and memory deficits. Fresh Gastrodia elata Blume (FG), the unprocessed raw tuber of Gastrodia elata Blume, has been reported to alleviate the symptoms of headache, convulsions, and neurodegenerative diseases, while the protective effects of FG on CRS-induced cognitive deficits remain unclear. This work aimed to evaluate the effects of FG on CRS-induced cognitive deficits through multiplex animal behavior tests and to furt...

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The effects of fresh Gastrodia elata Blume on the cognitive deficits induced by chronic restraint stress

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