Melatonin protects against NMDA-induced retinal ganglion cell injury by regulating the microglia-TNFα-RGC p38 MAPK pathway

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成果类型：

期刊论文

作者：

Zou, Jingling;Yang, Jia;Chen, Biyue;Jiang, Jikuan;Liu, Jingyuan;...

作者机构：

[Zou, Jingling; Jiang, Jikuan; Wang, Cong; Yang, Jia; Zhang, Lusi; Liu, Jingyuan; Zeng, Jun; Jiang, Bing] Cent South Univ, Dept Ophthalmol, Xiangya Hosp 2, Changsha, Peoples R China.

[Zou, Jingling; Jiang, Jikuan; Wang, Cong; Yang, Jia; Zhang, Lusi; Liu, Jingyuan; Zeng, Jun; Jiang, Bing] Hunan Clin Res Ctr Ophthalm Dis, Changsha, Peoples R China.

[Chen, Biyue] Chinese Peoples Liberat Army Med Sch, Beijing, Peoples R China.

[Yu, Juan; Peng, Qinghua] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.

[Yu, Juan; Peng, Qinghua] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Inflammation;Melatonin;Microglia;Retinal ganglion cell;Retinal neurodegenerative diseases;TNFα

期刊：

International Immunopharmacology

ISSN：

1567-5769

年：

2023

卷：

118

页码：

109976

DOI：

10.1016/j.intimp.2023.109976

基金类别：

National Natural Science Foundation of China [82070967, 81770930, 81700837]; Hunan Pro- vincial Innovation Foundation For Postgraduate [CX20210115]; Fundamental Research Funds for the Central Universities of Central South University [2021zzts0358]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Glaucoma, one of the most common ocular neurodegenerative diseases worldwide, is characterized by retinal ganglion cell (RGC) loss. There is a large body of literature that describes the neuroprotective role of melatonin against neurodegenerative diseases by regulating neuroinflammation, although the exact mechanism through which melatonin acts on RGC is still uncertain. This study assessed the protective effects of melatonin using a NMDA-induced RGC injury model, and studied the possible mechanisms involved in this process. Melatonin promoted RGC survival, improved retinal function, and inhib...

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Melatonin protects against NMDA-induced retinal ganglion cell injury by regulating the microglia-TNFα-RGC p38 MAPK pathway

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