期刊论文

中文

中国中西医结合消化杂志

1671-038X

2006

14

1

1-5

10.3969/j.issn.1671-038X.2006.01.001

湖南省科技厅资助项目（B0082）；

本校为第一机构

[目的]观察川芎嗪干预肝缺血再灌注损伤大鼠P-选择素表达,探索可能的病理机制,为预防治疗肝细胞缺血再灌注损伤提供依据.[方法]将64只SD大鼠随机分为4组,肉眼观察肝脏形态变化,光镜、电镜观察肝细胞形态变化,免疫组化SABC法检测肝组织中P-选择素表达.[结果]缺血再灌注组可见肝细胞水肿明显,伴空泡形成,间质充血水肿及炎性细胞浸润,再灌注6 h可见肝组织出现明显的点状坏死灶,并可见到灶性坏死;再灌注24 h肝组织可见多发性灶性坏死及片状坏死灶.川芎嗪干预组各时间点肝组织外观与正常肝相似,光镜下肝细胞无明显肿胀,有极少量空泡形成,但无变性或坏死,且间质无明显变化.免疫组化SABC法检测显示,缺血...

[Objective] To observe the pathologic changes of liver cell in ischemia-reperfusion injury rat under the microscope and electron microscope, and explore the pathologic mechanism of liver ischemia-reperfusion and the effects of ligustrazine. [Methods] Sixty~four Sprague-Danley （SD） rats were devided into four groups. Morphology of liver, hepatic tissue and expression of P- selectin in various groups were observed. [Results] In the hapetic ischemia-reperfusion group, dropsy of liver tissue was obvious and vacuole came into being. Histological d...