Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Xuexiang;Wu, Xian;Ouyang, Wen;Gu, Min;Gao, Zili;...

通讯作者：

Cao, Yong;Xiao, Hang

作者机构：

[Chen, Yunjiao; Cao, Yong; Chen, Xuexiang; Lin, Yanyin] South China Agr Univ, Coll Food Sci, Guangzhou 510642, Guangdong, Peoples R China.

[Wu, Xian; Xiao, Hang; Gao, Zili; Chen, Xuexiang; Song, Mingyue; Gu, Min] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA.

[Chen, Xuexiang] Guangzhou Med Univ, Coll Publ Hlth, Guangzhou 511436, Guangdong, Peoples R China.

[Chen, Yunjiao; Cao, Yong; Lin, Yanyin] Guangdong Prov Engn Res Ctr Bioact Nat Prod, Guangzhou 510642, Guangdong, Peoples R China.

[Ouyang, Wen] Hunan Univ Tradit Chinese Med, Coll Pharm, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Cao, Yong] S

[Xiao, Hang] U

[Cao, Yong] G

South China Agr Univ, Coll Food Sci, Guangzhou 510642, Guangdong, Peoples R China.

Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA.

语种：

英文

关键词：

Rubus corchorifolius L.f.;apoptosis;cell cycle;colon cancer;ent-kaur-2-one-16beta,17-dihydroxy-acetone-ketal

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2017

卷：

期：

页码：

1566-1573

DOI：

10.1021/acs.jafc.6b05376

基金类别：

University of International Cooperation in Science and Technology Innovation Platform Project of Guangdong [2013gjhz0003]; Agricultural Science and Technology Planned Projects of Guangzhou [2012A020602038]; South China Agriculture University

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

The tender leaves of Rubus corchorifolius L. f. have been consumed as tea for drinking in China since ancient times. In this study, a novel ent-kaurane diterpenoid was isolated and identified from R. corchorifolius L. f. leaves as ent-kaur-2-one-16β,17-dihydroxy-acetone-ketal (DEK). DEK suppressed the growth of HCT116 human colon cancer cells with an IC50value of 40 ±0.21 μM, while it did not cause significant growth inhibition on CCD-18Co human colonic myofibroblasts at up to100 μM. Moreover, DEK induced extensive apoptosis and S phase cell cycle arrest in the colon cancer c...

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Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis

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