Simultaneous determination of sulindac and its metabolites sulindac sulfide and sulindac sulfone in human plasma by a sensitive UPLC-PDA method for a pharmacokinetic study

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成果类型：

期刊论文

作者：

Huang, Wei-Hua;Shao, Li;Li, Shun-Xiang;Guo, Dong;Wang, Lian-Sheng;...

通讯作者：

Tan, Zhi-Rong

作者机构：

[Huang, Wei-Hua; Tan, Zhi-Rong; Zhang, Wei; Li, Zhi; Guo, Dong; Zhou, Hong-Hao; Chen, Yao; Wang, Lian-Sheng] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.

[Huang, Wei-Hua; Tan, Zhi-Rong; Zhang, Wei; Li, Zhi; Guo, Dong; Zhou, Hong-Hao; Chen, Yao; Wang, Lian-Sheng] Cent S Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China.

[Li, Shun-Xiang; Shao, Li] Hunan Univ Chinese Med, Sch Pharm, Changsha 410128, Hunan, Peoples R China.

[Peng, Xiang-Dong] Cent S Univ, Affiliated Teaching Hosp 3, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Tan, Zhi-Rong] C

Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.

语种：

英文

期刊：

Analytical Methods

ISSN：

1759-9660

年：

2014

卷：

期：

页码：

4679-4685

DOI：

10.1039/c4ay00730a

基金类别：

National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81001471, 81302850]; Foundation of Hunan Science Technology Department [2009FJ4008]; Young Teachers Boost Plan of Central South University [201012200133]; General Financial Grant from the China Postdoctoral Science Foundation [2013M531817]; Central South University [1681-7608040003]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

A sensitive, rapid and reliable ultra-performance liquid chromatography (UPLC) with Photo-Diode Array (PDA) detection method was developed for simultaneous determination of sulindac and its metabolites sulindac sulfide and sulindac sulfone in human plasma. The analytes were extracted by dichloromethane from human plasma using a liquid-liquid extraction method. The chromatographic separation was performed on a Waters Acquity UPLC with a Waters Acquity UPLC BEH C18 column (2.1 ×50 mm i.d., 1.7 μm) within 5 minutes. The mobile phase used for gradient elution consisted of ammonium formate...

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Simultaneous determination of sulindac and its metabolites sulindac sulfide and sulindac sulfone in human plasma by a sensitive UPLC-PDA method for a pharmacokinetic study

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