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Biology of cyclooxygenase-2: An application in depression therapeutics

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成果类型:
期刊论文
作者:
He, Ying;Han, Yuanshan;Liao, Xiaolin;Zou, Manshu;Wang, Yuhong
作者机构:
[Liao, Xiaolin; He, Ying; Wang, Yuhong; Zou, Manshu] Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha, Peoples R China.
[Han, Yuanshan] Hunan Univ Chinese Med, Dept Sci Res, Hosp 1, Changsha, Peoples R China.
[Wang, Yuhong] Hunan Prov Key Lab Prevent & Treatment Depress Dis, Changsha, Peoples R China.
[Wang, Yuhong] Hunan Key Lab Power & Innovat Drugs, State Key Lab Minist Training Bases, Changsha, Peoples R China.
语种:
英文
关键词:
COX-2;Depression;Pro-inflammatory cytokines;mechanism of action;cox-2 inhibitors
期刊:
Frontiers in Psychiatry
ISSN:
1664-0640
年:
2022
卷:
13
页码:
1037588
基金类别:
This work was supported by the National Natural Science Foundation of China (No. 82104846), the Natural Science Foundation of Hunan Province (Nos. 2022JJ40323 and 2022JJ80092), the Natural Science Foundation of Changsha (No. Kq2202266), and the Hunan Postgraduate Scientific Research Innovation Project (No. CX20220796).
机构署名:
本校为第一机构
院系归属:
第一中医临床学院
摘要:
Depressive Disorder is a common mood disorder or affective disorder that is dominated by depressed mood. It is characterized by a high incidence and recurrence. The onset of depression is related to genetic, biological and psychosocial factors. However, the pathogenesis is still unclear. In recent years, there has been an increasing amount of research on the inflammatory hypothesis of depression, in which cyclo-oxygen-ase 2 (COX-2), a pro-inflammatory cytokine, is closely associated with depression. A variety of chemical drugs and natural products have been found to exert therapeutic effects b...

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