期刊论文

Building of Hypertensive Heart Failure Rat Models

中文

湖南中医药大学学报

1674-070X

2017

37

3

245-248

10.3969/j.issn.1674-070X.2017.03.004

国家自然科学基金项目（81373550）；

本校为第一机构

目的 研制高血压引起的心衰大鼠动物模型.方法 将18只Dahl盐敏感性大鼠分为正常组和模型组并分别使用0.3%NaCl低盐饲料和8%NaCl高盐饲料喂养大鼠20周,观察大鼠行为及体征,检测大鼠血压、 血清氨基末端脑钠肽前体(N-terminal Pro-brain natriuretic peptide,NT-proBNP)含量,彩色超声多普勒检测大鼠左室射血分数(left ventricular ejec-tion fraction,LVEF)和左室短轴缩短率(left ventricular fractional shortening,LVFS)及电镜观察HE染色心肌细胞以及肾脏组织等.结果 正常组大鼠血压一直维持在140 mmHg左右,而模型组大鼠从进食高盐饲料后血压保持持续上升,最高可达250 mmHg;与正常组比较,模型组...

Objective To build the rat model of hypertension heart failure. Methods Eighteen Dahl salt sensitive rats were divided into normal group and model group feed by 0.3% NaCl low-salt and 8% NaCl high-salt for 20 weeks, respec-tively. After 20 weeks, the daily behavior and physical signs of the rats were observed. The blood pressure, serum N-termi-nal-pro-brain-natriuretic-peptide (NT-proBNP) content of the rats were observed. The left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were measured by color doppler ultrasound instrument. The HE dyed myocardial ...