期刊论文

The Influence of Changlong Dan(CLD) on the structure of neuron of hippocampal area in the Brain of Aging Mice

中文

湖南中医药大学学报

1674-070X

2001

21

1

9-10+19

10.3969/j.issn.1674-070X.2001.01.004

国家教委资助项目!［（94）99］；

本校为第一机构

为了阐明菖龙丹抗老年性痴呆作用与海马区神经元结构的关系，运用光镜和透射电镜观察了菖龙丹对自然衰老小鼠海马区形态的影响，结果显示老年对照组小鼠光镜下海马锥体细胞较青年对照组数量减少，细胞体积变小，神经元变性，分枝减少；电镜下海马神经细胞发生退化改变，核膜皱缩，呈波浪状，膜结构不清晰，核染色质浓缩，电子密度高，异染色质较多，部分胞浆细胞器向细胞核聚集，有的可见细胞核固缩。菖龙丹对其退化改变可有不同程度改善，使其神经元数量增多，胞体增大，分支增多，超微结构改善接近青年对照组。提示菖龙丹抗老年性痴呆的作用与其改善海马区神经元形态结构有关。

To explain relationship between the effect of CLD on senile Demention and neuron in hippocampal area. The change of natural aging mice's neuron in hippocampal area were studied by applying microscope and transilluminating electric microscope(EM). Results: Comparing with the young control, the old control mice's hippocampus had less small pyramid cells, the nerve cells denaturalizing and their branches reducing in the microscope. Hippocampal nerve cells were degenemiceing, with nucleus membrance crinkling like wave shape were not clear, and chromatin condensing with high electron density, heter...