期刊论文

英文

Frontiers in Molecular Neuroscience

1662-5099

2022

15

999938

10.3389/fnmol.2022.999938

This work was financially supported by the National Key Research and Development Program of China (No. 2018YFC1314401), Hunan Provincial Natural Science Foundation of China (Nos. 2018JJ3284, 2020JJ4803, 2022JJ2540, 2022JJ2615, 2021JJ70013, 2021JJ70089, and 2022JJ40728), The Scientific Research Project of the Hunan Health Commission (Nos. A202303096949, 20200620, and 202103092373), Special Project on Science and Technology Development and First-class Discipline Construction of Clinical Medicine Discipline of Hunan University of Chinese Medicine in the 13th Five-Year Plan Period (2091007), and Key Clinical Specialty Construction Project of the Hunan Health Commission (Improvement of Diagnosis and Treatment Ability of Severe Psychiatric Diseases in Hunan Province).

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ObjectiveIn this study, we aimed to characterize the plasma metabolic profiles of brain atrophy and alcohol dependence (s) and to identify the underlying pathogenesis of brain atrophy related to alcohol dependence. MethodsWe acquired the plasma samples of alcohol-dependent patients and performed non-targeted metabolomic profiling analysis to identify alterations of key metabolites in the plasma of BA-ADPs. Machine learning algorithms and bioinformatic analysis were also used to identify predictive biomarkers and investigate their possible roles in brain atrophy related to alcohol dependence. R...