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Network Pharmacology and In Vivo Experimental Verification of the Mechanism of the Qing'e Pill for Treating Intervertebral Disc Degeneration

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成果类型:
期刊论文
作者:
Jin, Hui;Ma, Huaiyu;Wu, Jie;Wu, Ruizhe;Xu, Haoran;...
通讯作者:
Zeng, Jingqi;Wang, F
作者机构:
[Ma, Huaiyu; Xu, Haoran; Wu, Jie; Wu, Ruizhe; Wang, F; Zeng, Jingqi; Zeng, JQ; Chen, Weixing; Wang, Fan; Jin, Hui] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Orthoped, Changsha 410005, Peoples R China.
[Wu, Jie; Wu, Ruizhe] Hunan Univ Chinese Med, Grad Sch, Changsha 410208, Peoples R China.
[Li, Linghui] China Acad Chinese Med Sci, Wangjing Hosp, Dept Sports Med, Beijing 100102, Peoples R China.
通讯机构:
[Wang, F ; Zeng, JQ] H
Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Orthoped, Changsha 410005, Peoples R China.
语种:
英文
关键词:
Intervertebral disc degeneration;Qing’e Pill;in vivo experiments;molecular mechanisms;molecular docking;network pharmacology.
期刊:
CURRENT COMPUTER-AIDED DRUG DESIGN
ISSN:
1573-4099
年:
2025
卷:
21
期:
4
页码:
534-548
基金类别:
National Natural Science Foundation of China [81904230]; Natural Science Foundation of Hunan Province [2023JJ60484]; General Guidance Project of Hunan Province Health Commission [D202304075958]; Youth Project of Hunan Provincial Department of Education [23B0344]; Research Student Innovation Project of Hunan University of Chinese Medicine [2023CX108]; General Project of Traditional Chinese Medicine Administration of Hunan Province [B2024079]
机构署名:
本校为第一且通讯机构
院系归属:
第二中医临床医学院
研究生院
摘要:
Objective The Qing’e Pill (QEP) is widely used to alleviate low back pain and sciatica caused by Intervertebral Disc Degeneration (IDD). However, its active components, key targets, and molecular mechanisms are not fully understood. The aim of this study is to elucidate the molecular mechanisms through which the QEP improves IDD using database mining techniques. The Qing’e Pill (QEP) is widely used to alleviate low back pain and sciatica caused by Intervertebral Disc Degeneration (IDD). However, its active components, key targets, and molecul...

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