期刊论文

Effects of Bushen Huoxue Fang on antibody of anti-zona pellucida in peripheral blood of mice with immune premature ovarian failure

中文

甘肃中医药大学学报

1003-8450

2010

27

3

9-11

10.3969/j.issn.1003-8450.2010.03.003

基金项目：2009年国家自然基金面上项目（30973771）,2008年湖南省教育厅科研项目（08C620）,2009年湖南省研究生科研创新项目（CX20098174）,湖南省中西医结合临床重点学科资助.

本校为第一机构

目的 研究补肾活血方对免疫性卵巢早衰小鼠外周血抗透明带抗体(AzpAb)的影响,为临床上运用中医药预防和治疗卵巢早衰提供实验依据.方法 以小鼠透明带3为抗原,皮下多点注射免疫Balb/c雌性小鼠,建立免疫性卵巢早衰模型.以补肾活血方低、中、高剂量进行治疗,并设倍美力为对照,ELISA法测定血清AzpAb含量.结果 与空白组比较,模型组AzpAb表达水平显著升高,2组比较差异有高度统计意义(P＜0.01);与模型组比较,补肾活血方各剂量组、倍美力组AzpAb表达水平均显著降低(P＜0.01);与倍美力组比较,高剂量组AzpAb表达水平有所降低,但2组比较无统计意义(P＞0.05),中、低剂量组显著高于倍美力组(P＜0.01);补肾活血...

Objective To study the effects of Bushen Huoxue Fang on antibody of anti-zona pellucida （AzpAb） in peripheral blood of mice with immune premature ovarian failure （POF） , and provide experimental basis for Chinese medicine of clinical prevention and treatment of premature ovarian failure. Methods The zona pellueida 3 of mice was regarded as antigen, immune POF models of Balb/c female mice were established by multi-point injection of the antigen. Used Bushen Huoxue Fang low, medium and high dose to treat, and prematin was regarded as control,...