期刊论文

Application study on Flos Lonicerae in pouched snus

中文

甘肃中医药大学学报

1003-8450

2022

39

2

28-32

10.16841/j.issn1003-8450.2022.02.07

110201801011:中国烟草总公司科技重大专项 XX-11:中国烟草总公司科技重大专项

本校为第一机构

目的 考察金银花有效成分绿原酸在口含烟中的释放特性.方法 将金银花提取物添加到袋装型口含烟中,采用药物溶出仪测定口含烟中烟碱和绿原酸的体外释放度,采用高效液相色谱(HPLC)法测定口含烟中绿原酸、烟碱的含量,分别采用Higuchi方程、零级释放模型和一级释放模型对溶出数据进行拟合,采用相似因子f2对烟碱溶出曲线进行评价.结果 烟碱、绿原酸的体外释放均与一级动力学方程拟合程度最高,绿原酸在40 min内基本释放完全,2种口含烟的烟碱溶出曲线相似,f2 = 82.08.结论 金银花提取物不影响口含烟烟碱的释放,可用于袋装型口含烟.

Objective To investigate the release characteristics of effective constituent chlorogenic acid from Flos Lonicerae in pouched snus.Methods Flos Lonicerae extract was added to pouched snus.The release degree in vitro of nicotine and chlorogenic acid therein was determined by drug dissolution tester,and the content of chlorogenic acid and nicotine therein was determined by high performance liquid chromatography(HPLC).The dissolution data fitted Higuchi equation,zero order release model and first-order release model,respectively.And the nicotine dissolution curve was evaluated by using similarity...