PB@PDA@Ag nanosystem for synergistically eradicating MRSA and accelerating diabetic wound healing assisted with laser irradiation

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成果类型：

期刊论文

作者：

Tong, Chunyi;Zhong, Xianghua;Yang, Yuejun;Liu, Xu;Zhong, Guowei;...

通讯作者：

Liu, B;Wang, W

作者机构：

[Liu, Bin; Liu, B; Xiao, Chang; Zhong, Guowei; Tong, Chunyi] Hunan Univ, Coll Biol, Changsha 410082, Peoples R China.

[Yang, Yuejun; Zhong, Xianghua; Yang, Xiaoping] Hunan Normal Univ, Sch Med, Changsha 410125, Peoples R China.

[Liu, Xu; Wang, Wei] Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.

[Liu, Bin] Ningxia Med Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, NHC Key Lab Metab Cardiovasc Dis Res, Yinchuan 750004, Ningxia, Peoples R China.

通讯机构：

[Liu, B ; Wang, W ] H

Hunan Univ, Coll Biol, Changsha 410082, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Diabetic wound;MRSA;PB@PDA@Ag nanocomposites;Photothermal effect

期刊：

Biomaterials

ISSN：

0142-9612

年：

2020

卷：

243

页码：

119936

DOI：

10.1016/j.biomaterials.2020.119936

基金类别：

CRediT authorship contribution statement Chunyi Tong: Conceptualization, Methodology, Resources. Xianghua Zhong: Conceptualization, Investigation, Writing - original draft. Yuejun Yang: Validation, Formal analysis, Writing - review & editing. Xu Liu: Validation. Guowei Zhong: Data curation. Chang Xiao: Data curation. Bin Liu: Writing - original draft, acquisition, Project administration. Wei Wang: acquisition, Writing - review & editing. Xiaoping Yang: Visualization.

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

The ever-growing threats of multidrug-resistant bacterial infection and chronic wound healing have created an imperative need for the development of novel antibacterial materials and therapeutic strategies, especially for diabetic patients infected with multidrug-resistant bacteria. In this work, the nanocomplexes named as PB@PDA@Ag were used for eradicating multidrug-resistant bacteria and accelerating wound healing of MRSA-infected diabetic model with the assistance of laser irradiation. In vitro results revealed that the combinational strate...

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PB@PDA@Ag nanosystem for synergistically eradicating MRSA and accelerating diabetic wound healing assisted with laser irradiation

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