Cholesterol in LDL receptor recycling and degradation

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, Hui-xian;Zhang, Min;Long, Shi-yin;Tuo, Qin-hui;Tian, Ying;...

通讯作者：

Zhang, Cai-ping;Liao, Duan-fang

作者机构：

[Yang, Hui-xian] Univ South China, Med Coll, Inst Cardiovasc Dis, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Liao, Duan-fang; Chen, Jian-xiong; Tuo, Qin-hui] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Tian, Ying; Long, Shi-yin; Yang, Hui-xian; Zhang, Cai-ping; Zhang, Min; Liao, DF] Univ South China, Med Coll, Dept Biochem & Mol Biol, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Chen, Jian-xiong] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, University, MS 38677 USA.

通讯机构：

[Zhang, CP; Liao, DF] U

Univ South China, Med Coll, Dept Biochem & Mol Biol, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Dyslipidemia;IDOL;LDL-C;LDLR;PCSK9;SREBP2

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2020

卷：

500

页码：

81-86

DOI：

10.1016/j.cca.2019.09.022

基金类别：

National Nature Science Fund of ChinaNational Natural Science Foundation of China [81600291, 81673722, 81670268, 31871169]; Nature Science Fundation of Hunan province [2018JJ2348, 2018JJ2346]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [0223-0002-0002000-54]; Construct Program of the Pharmaceutical Science Key Discipline in Hunan Province

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

The SREBP2/LDLR pathway is sensitive to cholesterol content in the endoplasmic reticulum (ER), while membrane low-density lipoprotein receptor (LDLR) is influenced by sterol response element binding protein 2 (SREBP2), pro-protein convertase subtilisin/kexin type 9 (PCSK9) and inducible degrader of LDLR (IDOL). LDL-C, one of the risk factors in cardiovascular disease, is cleared through endocytosis recycling of LDLR. Therefore, we propose that a balance between LDLR endocytosis recycling and PCSK9-mediated and IDOL-mediated lysosomal LDLR degradation is responsible for cholesterol homeostasis ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Cholesterol in LDL receptor recycling and degradation

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问