Anti-inflammatory effects of higenamine (Hig) on LPS-activated mouse microglia (BV2) through NF-κB and Nrf2/HO-1 signaling pathways

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成果类型：

期刊论文

作者：

Yang, Songwei;Chu, Shifeng;Ai, Qidi;Zhang, Zhao;Gao, Yan;...

通讯作者：

Chen, NH

作者机构：

[Ai, Qidi; Li, Xun; He, Qinghui; Pan, Yawen; Peng, Ye; Chen, Naihong; Lin, Meiyu; Yang, Songwei; Hu, Yaomei; Liu, Yingjiao] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Ai, Qidi; Li, Xun; He, Qinghui; Pan, Yawen; Peng, Ye; Chen, Naihong; Lin, Meiyu; Yang, Songwei; Hu, Yaomei; Liu, Yingjiao] Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Hunan, Peoples R China.

[Li, Xun; Peng, Ye; Gao, Yan; Zhang, Zhao; Yang, Songwei; Hu, Yaomei; Chen, Naihong; Liu, Yingjiao; Chu, Shifeng] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Li, Xun; Peng, Ye; Gao, Yan; Zhang, Zhao; Yang, Songwei; Hu, Yaomei; Chen, Naihong; Liu, Yingjiao; Chu, Shifeng] Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, Beijing 100050, Peoples R China.

通讯机构：

[Chen, NH ] H

Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

BV2 microglia;Higenamine;Inflammatory response;NF-κB;Nrf2/HO-1;Oxidative stress

期刊：

International Immunopharmacology

ISSN：

1567-5769

年：

2020

卷：

期：

页码：

106629

DOI：

10.1016/j.intimp.2020.106629

基金类别：

This work was supported by the National Natural Science Foundation of China (81730096, 81873026, 81503275); the Drug Innovation Major Project (2018ZX09711001-002-007, 2018ZX09711001-003-005, 2018ZX09711001-009-013); Beijing Natural Science Foundation (7192135); CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-1-004); Project of NDRC and State Administration of Traditional Chinese Medicine (ZYBZH-Y-HUN-24); Hunan Engineering Technology Center of Standardization and Function of Chinese CRediT authorship contribution statement Songwei Yang: Conceptualization, Investigation, Writing - original draft. Shifeng Chu: Formal analysis, acquisition. Qidi Ai: Data curation, Writing - review & editing. Zhao Zhang: Formal analysis, Methodology. Yan Gao: Resources, Software. Meiyu Lin: Project administration. Yingjiao Liu: Investigation, Software. Yaomei Hu: Visualization, Software. Xun Li: Investigation, Software. Ye Peng: Investigation, Visualization. Yawen Pan: Data curation, Investigation. Qinghui He: Investigation,

机构署名：

本校为第一且通讯机构

摘要：

Microglia are the most widely equipped protective cells in the brain and play a pivotal role in the development of neurological diseases. Inflammatory response and oxidative stress are critical risk factors in the activation of microglia which may cause various neurological diseases. Higenamine (Hig), a plant-based alkaloid and isolated from Aconite tuber, exhibits various properties and is mainly applied to treat heart failure. In addition, Hig expresses potential protective effects for neurodegenerative diseases. However, the effects and mechanisms of Hig on lipopolysaccharide (LPS) activate...

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Anti-inflammatory effects of higenamine (Hig) on LPS-activated mouse microglia (BV2) through NF-κB and Nrf2/HO-1 signaling pathways

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