期刊论文

中文

中医药导报

1672-951X

2012

18

3

56-58

10.13862/j.cnki.cn43-1446/r.2012.03.048

湖南省科技厅、湖南省教育厅中药现代化重点实验室资助项目(2007WK2033)；

本校为第一机构

目的:建立四磨汤口服液HPLC指纹图谱,明确辛弗林与柚皮苷在图谱中的归属。方法:采用HPLC法,建立四磨汤口服液自制样品在283 nm检测波长下的指纹图谱,以色谱峰保留时间为考察指标,应用辛弗林、柚皮苷对照品及枳壳中药对照药材,对四磨汤口服液HPLC图谱特征峰进行标定,从而获取辛弗林和柚皮苷的归属信息。结果:建立了四磨汤口服液自制样品HPLC特征指纹图谱,标示出8个共有峰,且5个是明显特征峰,各峰分离良好,其中2个明显特征峰的保留时间均与辛弗林、柚皮苷色谱吻合,也与枳壳色谱中的2个特征峰吻合。结论:该方法简便、重现性好,既有利于制定四磨汤口服液质量控制方法,也为深入四磨汤口服液药效物质基...

Objective： To establish fingerprint of self-made simotang oral liquid by HPLC,and to analyze synephrine and naringin chemical component classification in it. Method： The chromatographic fingerprints of self-made Simotang Oral liquid and the relevant fractions of synephrine, naringin and fructusaurantii reference substanc were configured by I-IPLC analysis. The correlation was evaluated with retention time as indices at the wavelength of 253 nm. Result： The fingerprint of antidepressant fraction of simotang oral liquid was successfully establ...