期刊论文

中文

中医药导报

1672-951X

2013

7

86-88

10.13862/j.cnki.cn43-1446/r.2013.07.044

2009-156:湖南省大学生研究性学习和创新性实验计划 :国家中医药管理局中医药重点学科建设 :湖南省中医药管理局方剂学重点学科

本校为第一机构

　　目的：探讨当归拈痛汤及其拆方对急性痛风性关节炎大鼠血尿酸的影响并观察大鼠肾脏脏器指数及关节滑膜的病理改变。方法：采用腺嘌呤和乙胺丁醇造成大鼠体内高尿酸血症模型，在大鼠高尿酸前提下，采用尿酸钠（MUS）诱导大鼠急性痛风性关节炎模型。将60只大鼠随机分为正常组、模型组、全方组、茵陈组、羌活组、西药组，每组10只。正常组、模型组均予生理盐水治疗，全方组、茵陈组、羌活组、西药组分别予当归拈痛汤、当归拈痛汤拆方1、当归拈痛汤拆方2、秋水仙碱治疗。测定各组大鼠血尿酸值及肾脏脏器指数，并观察大鼠关节滑膜的病理改变。结果：与模型组比较，西药组、茵陈组、羌活组、全方组...

Objective: To investigate the effects of Chinese Angelica Pain-Assuaging Decoction and its disassembled de-coction on serum uric acid, renal organ index and joint synovium in rats. Methods: Hyperuricemia model in Rats was repli-cated by injection of adenine and ethambutol. 60 SPF rats were randomly divided into normal group, model group, Chinese Angelica Pain-Assuaging Decoction group, Siphonostegia group, Notopterygium group and Western Medicine group, 10 rats in each group. Rats were given physiological saline in normal group and model group by intragastric administration, Chinese An-gelica ...