期刊论文

The Effects of Fu-zheng Yi-liu Ointments on Spleen-deficiency Syndrome of Adjuvant Chemotherapy Colorectal Cancer

中文

中医药导报

1672-951X

2014

20

5

26-29

10.13862/j.cnki.cn43-1446/r.2014.05.009

基金项目：湖南中医药大学青年教师科研基金课题（99820001-104）

本校为第一机构

目的:观察扶正抑瘤膏对结直肠癌辅助化疗（mFOLFOX6方案）后脾虚证患者免疫水平影响,并探讨其作用机制。方法:将40例结直肠癌辅助化疗后脾虚证患者随机分为两组,每组20例,对照组采用贞芪扶正颗粒;治疗组采用扶正抑瘤膏治疗;疗程均为4周。治疗前后检测其外周血中CD4+CD25+调节性T细胞（regulatory T cells,Treg）、肿瘤坏死因子-α（TNF-α）及白介素12（IL-12）含量变化,根据2002版《中药新药临床研究指导原则》行中医脾虚证候改善疗效评价,并根据WHO抗癌药物急性及亚急性毒性反应分度标准进行分级统计。结果:结直肠癌辅助化疗后脾虚证患者CD4+CD25+细胞含量较健康人明显升高（P

Objective： To explore the effect and mechanism of Fu-zheng Yi-liu Ointments（FYO） on spleen deficiency syn- drome of adjuvant chemotherapy colorectal cancer（ACCRC）.Methods： The 40 ACCRC patients were randomly assigned to two groups, 20 cases in each; Patients were treated by Zhen-qi Fu-zheng Granules in control group and Fu-zheng Yi-liu Oint- ments in treatment group. Both of the groups are required four weeks therapy.The CD4＋CD25＋regulatory T （Treg）cells, tumor necrosis factor-α（TNF-α）and interleukin-12 （IL-12）in peripheral bloo...