期刊论文

The Influence of Acupuncture Combined with Aerobic Exercise to Chronic Ischemic Rat Models with Cognitive Deficits ICAM-1 and Related Factors

中文

河南中医

1003-5028

2015

21

7

9-12

10.13862/j.cnki.cn43-1446/r.2015.07.004

湖南省中医药管理局课题（2012120）；

本校为第一机构

目的:观察针刺联合有氧运动对缺血性认知障碍大鼠行为学及海马神经元细胞间黏附分子-1（ICAM-1）及相关因子TNF-α、IL-6的影响。方法:采用改良双侧颈总动脉分期永久结扎法,制备缺血模型,设立空白组和假手术组,通过水迷宫实验测验小鼠的记忆能力,免疫组化法检测大鼠海马ICAM-1表达水平及Elisa法检测血清中TNF-α、IL-6含量。结果:大鼠行缺血造模后ICAM-1表达显著增加。经干预治疗后,单纯有氧运动组和单纯针刺组大鼠海马ICAM-1表达下降,而有氧运动联合针刺治疗组大鼠海马ICAM-1表达较模型组显著下降。与缺血模型组比较,针刺干预组、有氧运动组大鼠血清TNF-α、IL-6含量降低,针刺和有氧运动联合干...

Objective： To observe the effects of acupuncture combined with aerobic exercise on the behaviors and the expression of ICAM-1, TNF--α and IL-6in hippo campus of ischemic cognitive impairment in rats model. Methods： Modified ligation of bilateral common carotid artery in installment permanent prepared method to prepare of ischemia model in rats model, set up the blank group and control group. Through the water maze experiment test memory ability of mice, immunohisto-chemical method to detect the rat hippocampal ICAM-1 expression level and ser...