Objective: To optimize the prescription of Binghe Lotion. Methods: The three indicators of bacteriostatic action and irritating were evaluated. (1) original prescription, (2)original prescription in addition to Chinese Prickly Ash, (3)original prescription in addition to Chinese Prickly Ash and to add Cortex Pseudolaricis, (4)original prescription in addition to Chinese Prickly Ash, Gentian and to add Cortex Pseudolaricis, Cnidii Fructus so on four kind of prescription were optimized. Results: Integrated score from high to low order ...