期刊论文

Protective Effects of Lingyangjiao （Antelope Horn） and Gouteng （Uncariae） on Brain Injury Induced by Febrile Seizures during Development in Rats

中文

中医药导报

1672-951X

2017

23

19

26-28

10.13862/j.cnki.cn43-1446/r.2017.19.008

湖南省科技计划项目（2015JC3076）； 湖南省教育厅青年科学基金项目（16B195）；

本校为第一机构

目的：探讨羚羊角与钩藤联用对高热惊厥所致发育期大鼠脑损伤的保护作用。方法：筛选50只大鼠随机分为空白组、模型组、羚羊角组、钩藤组、羚羊角-钩藤组,每组10只,各药物组大鼠按10 m L/kg给予相应药液,空白组给予等容积蒸馏水。1次/d,连续21 d。给药60 min后,置于（45±0.5）℃恒温水浴箱热水浴实验,隔日1次,连续10次,惊厥发作后,立即取出,擦干,观察大鼠发生惊厥的潜伏时间及惊厥发作持续时间。末次给药24 h后,各组取5只大鼠麻醉处死,取海马进行HE染色并于光镜下观察。结果：羚羊角-钩藤组、羚羊角组及钩藤组在高热惊厥发生后海马CA1区神经细胞病理损伤程度有所减轻,其中羚羊角-钩藤组减轻更明...

Objective： To study the protective effect of Lingyangjiao （Antelope horn） and Gouteng （Uncariae） on brain injury induced by febrile seizures in rats. Methods： The 50 rats were randomly divided into blank group, model group, antelope horn group, uncaria group, antelope horn and uncaria group, ten rats in each. The rats were given liquid medicine with 10 mL/kg in each group, and the blank group was given the same volume of distilled water, 1 times/day, for 21 days. The rats were placed in （45±0.5）℃ constant temperature water bath hot wa...