期刊论文

中文

中医药导报

1672-951X

2018

24

8

15-18

10.13862/j.cnki.cn43-1446/r.2018.08.005

本校为第一机构

目的：探讨心痛泰颗粒对动脉粥样硬化小鼠血脂及ICAM-1、VCAM-1影响的研究。方法：将Apo E-/-小鼠造模后随机分为模型组、心痛泰低、高剂量组和他汀组,每组10只,分别予以生理盐水、心痛泰低、高剂量及阿托伐他汀钙片灌胃;野生型小鼠作为空白对照组,予普通饲料正常喂养。治疗8周后检测血浆TC、TG、LDL-C、HDL-C,血清ICAM-1、VCAM-1变化情况。结果：心痛泰颗粒低、高剂量组、他汀组TC、TG、LDL-C水平均低于模型组,且心痛泰颗粒高剂量组低于心痛泰低剂量组,差异均有统计学意义（P〈0.05）;心痛泰颗粒低剂量组、高剂量组、他汀组ICAM-1、VCAM-1水平均低于模型组,差异均有统计学意义（P〈0.05）,且高...

Objective: To explore the effects of Xintongtai granule on blood lipid and ICAM-1, VCAM-1 in atherosclerotic mice. Methods: ApoE-/- mice were randomly divided into model group, low-dose Xintongtai granule group, high-dose Xintongtai granule group and statin group, with 10 mice in each group. The physiological saline, low-dose Xintongtai granule, high-dose Xintongtai granule and atorvastatin calcium tablet were administered respectively. The wild type mice were fed normally as the blank control. After 8 weeks of treatment, plasma TC, TG, LDL-C a...