期刊论文

中文

中医药导报

1672-951X

2018

24

16

57-60

10.13862/j.cnki.cn43-1446/r.2018.16.018

湖南省教育厅高校创新平台开放基金资助项目（10K045）;湖南省教育厅重点科学研究项目（17A157）；

本校为第一机构

目的:研究龙丹腰痹宁对腰椎间盘突出症模型大鼠血细胞及血清TNF-α、IL-1β、β-NGF细胞因子表达的影响.方法:采取大鼠自体髓核移植法建立腰椎间盘突出症模型.将实验大鼠分为8组, 分别为空白组、假手术组、龙丹腰痹宁低、中、高剂量组、中药对照组、西药对照组.给药21 d后处死大鼠, 断头取血测血细胞及其分类, ELISA法测定血清细胞因子TNF-α、IL-1β、β-NGF表达情况.结果:假手术组和模型组大鼠白细胞总数明显高于空白组 (P＜0.05);龙丹腰痹宁低、中、高剂量组、中药对照组、西药对照组白细胞总数均明显低于模型组 (P＜0.05).模型组TNF-α、IL-1β明显高于空白组与假手术组 (P＜0.05);龙丹腰痹...

Objectives: To study the effects of Longdan Yaobi'ning Pellets on blood cells and serum cytokine expressions of TNF-α, IL-1β and β-NGF in Lumbar intervertebral disc herniation rats. Methods: A rat model of lumbar intervertebral disc herniation was established by transplanting autologous nucleus pulposus. The rats were randomly classified into following 8 groups: blank group, sham group, model group, Longdanyaobining Pellets (low dose) group, Longdanyaobining Pellets (medium dose) group, Longdanyaobining Pellets (high dose) group, TCM control...