期刊论文

Effect of Baihe Dihuang Decoction（百合地黄汤） on IL-1β and Neurotransmitter 5-HT in Depression Model Rats

中文

中医药导报

1672-951X

2018

24

16

30-33

10.13862/j.cnki.cn43-1446/r.2018.16.009

(2015JC3077):湖南省科技厅课题资助

本校为第一机构

目的:观察百合地黄汤对慢性不可预见性应激抑郁大鼠模型血清炎症因子及其海马5-HT表达水平的影响, 探究其抗抑郁的作用机理.方法:将60只SD大鼠随机分为正常组、模型组、百合地黄汤低剂量组、百合地黄汤高剂量组、湘百合地黄汤组、氟西汀组, 每组10只.采用孤养加慢性温和不可预知性应激的方法建立慢性应激抑郁大鼠模型, 造模时间为28 d, 造模结束后, 通过旷场实验, 强迫游泳实验评价大鼠的抑郁样行为, ELISA法检测各组大鼠血清抗炎因子IL-1β的水平变化, 免疫组化法检测大鼠海马神经递质5-HT的表达.结果:模型组大鼠的自主活动次数明显少于正常组, 强迫游泳不动时间明显长于正常组, 血清IL-1β含量...

Objective： To observe the effeet of Baihe Dihuang Decoction on the changes of serum anti-in- flamlnatory cytokines and neurotransmitter in rats with chronic unpredictable stress （CUMS） depression and to ex- plore its antidepressant mechanism. Methods： The 60 SD rats were randomly divided into blank control group, depression model group, low dose Baihe Dihuang Decoction group, high dose Baihe Dihuang Decoction, Xiang- Baihe Dihuang Deeoction group and fluoxetine group. The rats model of chronic stress depression was estab- lished by solitary...