期刊论文

中文

中医药导报

1672-951X

2019

25

18

27-31

10.13862/j.cnki.cn43-1446/r.2019.18.007

湖南省自然科学基金项目（2016JJ6116）； 湖南省自然基金青年基金项目（2019JJ50471）；

本校为第一机构

目的:研究天麻钩藤膏对自发性高血压心肌肥厚大鼠心脏重构的影响,并探讨其作用机制。方法:以突变系-自发性高血压大鼠（SHR）建立大鼠心肌肥厚模型。50只大鼠随机分为模型组（蒸馏水）,卡托普利片阳性药物组（卡托普利组,0.025 g/kg）,天麻钩藤膏低、中、高剂量组（5.36 g/kg、11.34 g/kg、24.36 g/kg）,每组10只,10只WKY大鼠为空白对照组（蒸馏水）,灌胃30 d。给药结束后检测大鼠血清SOD、MDA、NO和内皮素-1含量并观察心肌细胞的形态。结果:模型组大鼠心脏质量指数、心肌细胞肥大指数明显高于空白对照组,差异有统计学意义（P

Objective:To study the protective effect of Tianma Gouteng Ointment on cardiac remodeling in spontaneously hypertensive rats with myocardial hypertrophy and to explore its mechanism.Methods:Rat model of cardiac hypertrophy was established by spontaneous mutation of spontaneously hypertensive rats (SHR).Successful rats (n=50) were randomly divided into model control group (given distilled water),captopril positive drug control group (given captopril 0.025 g/kg),Tianma Gouteng Ointment group (given 5.36 g/kg,11.34 g/kg,24.36 g/kg respectively),blank control group (given distilled water).Another ...