期刊论文

Clinical Research of Wenyang Zhenxi Granules (温阳振衰颗粒)combined with Levosimendan in Chronic Heart Failure Patients with Yang Deficiency and Water Flooding Syndrome

中文

中医药导报

1672-951X

2019

25

6

82-85,94

10.13862/j.cnki.cn43-1446/r.2019.06.023

国家自然科学基金项目（81173213）；

本校为第一机构

目的:研究温阳振衰颗粒对慢性心力衰竭阳虚水泛证患者心功能、运动耐力和血清基质金属蛋白酶-2(MMP-2)、N-端脑钠肽前体(NT-proBNP)、C反应蛋白(CRP)的影响。方法:将84例慢性心力衰竭阳虚水泛证患者随机分成对照组与治疗组,每组42例。对照组患者采用左西孟旦治疗,治疗组患者在对照组基础上采用温阳振衰颗粒治疗。观察并比较两组患者的临床疗效、心功能、运动耐力、血清MMP-2、NT-proBNP、CRP表达水平及不良反应情况。结果:治疗组患者心力衰竭总有效率为92.86%,对照组患者心力衰竭总有效率为71.42%,治疗组优于对照组(χ^2=6.574,P=0.010);治疗组患者心功能总有效率为85.72%,对照组患者心功能总有...

Objective: To investigate effect of Wenyang Zhenxi granules combined with levosimendan on cardiac function, exercise endurance, serum matrix metalloproteinase-2 (MMP-2), N-tenninal pro brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP) in chronic heart failure (CHF) patients with Yang deficiency and water flooding syndrome, and to provide an effective theoretical basis for better treatment of CHF patients. Methods: 84 cases of CHF patients with Yang deficiency and water flooding syndrome were selected and equally divided into two groups. The control group received the levosimendan...