期刊论文

中文

中医药导报

1672-951X

2020

26

5

8-15+22

10.13862/j.cnki.cn43-1446/r.2020.05.003

国家自然科学基金项目(81973670)。

本校为第一机构

目的:运用网络药理学及分子对接技术探究疏风解毒胶囊治疗新型冠状病毒肺炎（COVID-19）的潜在分子机制。方法:检索计算系统生物学实验室数据库和分析平台（TCMSP）获得疏风解毒胶囊所有有效活性成分的干预靶点,并与GeneCards数据库中的新型冠状病毒肺炎疾病基因靶标相映射得到交集靶标;通过Cytoscape3.7.0构建"药物-活性成分-靶标"网络;通过String得到交集靶标的PPI网络;运用数据包进行基因本体（GO）功能富集分析和基于京都基因与基因组百科全书（KEGG）通路富集分析,预测其作用机制。将疏风解毒胶囊中关键有效成分化合物与PPI中核心蛋白进行分子对接。结果:"药物-活性成分-靶标"网络图中涉及...

Objective:To investigate the potential target and mechanism of Shufeng Jiedu Capsule for Novel coronavirus pneumonia(COVID-19)by using network pharmacology and molecular docking technique.Methods:The active components of Shufeng Jiedu Capsule were retrieved by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)database,and the target genes of active components were selected by AMDE parameters.The relevant target genes of Novel coronavirus pneumonia were retrieved from OMIM and Gene Cards database,and the target genes of active components were matched with Sh...