期刊论文

中文

中医药导报

1672-951X

2020

26

8

8-11

10.13862/j.cnki.cn43-1446/r.2020.08.003

81673955:国家自然科学基金 2018ZYX43:湖南中医药大学中医学一流学科开放基金 20200592:湖南省卫生计生科研计划项目 :湖南中医药大学中医学国内一流建设学科

本校为第一机构

目的:探讨益心泰颗粒对慢性心力衰竭心气虚兼血瘀水停证大鼠的影响.方法:采用丙基硫氧嘧啶(PTU)混悬液灌胃及阿霉素(ADR)腹腔注射复制慢性心力衰竭心气虚兼血瘀水停证大鼠模型.将造模成功的大鼠随机分为模型组、益心泰颗粒高剂量组、益心泰颗粒中剂量组、益心泰颗粒低剂量组和曲美他嗪组;另设正常对照组.各药物组灌胃给予相应药物,模型组和正常对照组大鼠灌胃同等体积的蒸馏水,1次/d,共4周.实验结束后检测心率、尿量、力竭时间、左室射血分数(LVEF)、血清BNP、全心质量指数(HMI)水平.结果:各药物组大鼠的心率、血清BNP、HMI值均明显低于模型组(P＜0.05或P＜0.01),而尿量、力竭时间、LVEF均明显高...

Objective: To explore the effect of Yixintai Granules(YXTG) on chronic heart failure(CHF) rat model with Xin-qi deficiency complicated blood stasis and edema syndrome. Methods: CHF rat model with Xinqi deficiency complicated blood stasis and edema syndrome was established by PTU suspension and intraperitioneally injected with ADR solution. Successfully modeled rats were divided into the model group, the high,middle, and low dose YXTG group, and the trimetazidine group. Besides, a normal control group was set up.Each group was given corresponding drugs by gavage. Equal volume of physiological s...